MODE OF ACTION OF STREPTOMYCIN ON TYPE b H. INFLUENZAE

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MODE OF ACTION OF STREPTOMYCIN ON TYPE b H. INFLUENZAE

1. Of fourteen patients with type b H. influenzae infections treated with streptomycin alone ten recovered promptly; in three of the four remaining cases failure was proved to be due to emergence of resistance of the organisms to streptomycin. 2. The rapid development of resistance to 1000 units of streptomycin per cc. during treatment argues against metabolic adaptation of the bacteria. 3. Car...

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MODE OF ACTION OF STREPTOMYCIN ON TYPE b HEMOPHILUS INFLUENZAE

In all of ten strains of H. influenzae examined prior to exposure to streptomycin a very small fraction of the bacteria formed colonies in the presence of 1,000 units of streptomycin per cc. These variant organisms possess the characteristics of bacterial mutants. 1. Different independent cultures of the same strain on different occasions, and even cultures seeded in a single test with the same...

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Haemophilus influenzae, a major cause of meningitis in young children leading to death and other neurological sequelae. The disease leaves 15 to 35% of the survivors with permanent disabilities, such as, mental retardation or deafness. Despite the availability of new and more powerful antibiotics children with Hib meningitis still suffer from high mortality or morbidity. The emergence of multir...

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ژورنال

عنوان ژورنال: Journal of Experimental Medicine

سال: 1947

ISSN: 1540-9538,0022-1007

DOI: 10.1084/jem.85.4.329